What it does: Citrulline plays a key role in the urea cycle to help remove ammonia from the body and supports increased nitric oxide production, promoting vascular health and improved circulation.
How it is used: People most often use citrulline in pre-workout or endurance supplements to support workout performance, increased blood flow (muscle pumps), and muscle recovery after exercise.
Natural sources and supplement forms: Watermelon is the best-known natural source of citrulline. Supplement forms include L-citrulline and citrulline malate, which are available as powders or capsules.
Why it appears in supplement formulas: Citrulline is included to support better exercise endurance, training performance, and efficient muscle recovery through enhanced blood flow and waste removal.
What to know before use: Most people tolerate citrulline well, but those with kidney concerns or taking blood pressure medication should seek medical guidance before using citrulline supplements.
Interesting Fact
Citrulline: A Watermelon-Derived Amino Acid
Citrulline is a naturally occurring amino acid first discovered in watermelon, which is one of the richest sources in nature. In the body, citrulline is involved in the urea cycle—a process that helps remove excess ammonia—making it a unique nutrient often included in supplements targeted for active lifestyles.
